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It really gets to you, 8 letters
Major personal annoyance, 8 letters
Minor irritant: 2 words, 8 letters
Particular annoyance, 8 letters
Political blog feature, often, 8 letters
Waiting in line, for some, 8 letters
Failed Facebook game where household animals piss you off?, 9 letters
With 38A and 57A, this puzzle's theme, 10 letters
Arnold on Green Acres is one, 6 letters
It may be potbellied, 6 letters
Wilbur, to Fern, in Charlotte's Web, 6 letters
Personal undertaking, 10 letters
Piece of political pork, perhaps, 10 letters