(LXXX - I) x (XX - I), 3 letters
1501, in ancient Rome, 3 letters
1501, in old Europe, 3 letters
1501, in Roman numerals, 3 letters
1501, on a monument, 3 letters
16th-century opener, 3 letters
Century-starting year, 3 letters
Early 16th century date, 3 letters
First year of the XVIth century, 3 letters
IX years after Columbus's voyage, 3 letters
Start of the 16th century, 3 letters
Start of the sixteenth century, 3 letters
Start of the XVIth century, 3 letters
When Michelangelo started David, 3 letters
Year before Columbus's fourth voyage, 3 letters
Year before which books known as incunabula were printed, 3 letters
Year in a voyage by Amerigo Vespucci, 3 letters
Year in Alexander VI's reign, 3 letters
Year in an Amerigo Vespucci voyage, 3 letters
Year in Henry VII's reign, 3 letters
Year in Ivan the Great's rule, 3 letters
Year in Luther's time, 3 letters
Year in which Michelangelo began work on David, 3 letters
Year Michelangelo began David, 3 letters
Year Michelangelo began work on David, 3 letters
Year that Michelangelo began work on David, 3 letters
Year that Michelangelo sculpted the Piet, 3 letters
Year Vespucci sailed to the New World, 3 letters
Lure of New Orleans, 7 letters
1502, on a monument, 4 letters
Early 16th century date, 4 letters
Early 16th-century year, 4 letters
Starting year of Columbus's last voyage, 4 letters
Ten years after Columbus came over, 4 letters
Wittenberg University's founding date, 4 letters
Year in Louis XII's reign, 4 letters
Year in which Columbus began his last voyage, 4 letters
Year of Columbus's fourth voyage, 4 letters
Year of Columbus's last trip to the New World, 4 letters
Year of Columbus's last voyage, 4 letters
Year of fourth voyage of Columbus, 4 letters
Year when Columbus named Honduras, 4 letters
When Leonardo began painting the Mona Lisa, 5 letters
When Leonardo painted the Mona Lisa, 5 letters
Year Hieronymus Bosch painted the The Garden of Earthly Delights, 5 letters
Year of Popes Pius III and Julius III, 5 letters
Year of the death of Pope Paul III, 4 letters
First year of Wai Ren's rule during the Shang dynasty, 6 letters
Early 16th century date, 4 letters
XII years after Columbus's famous voyage, 4 letters
XII years after Columbus's first voyage, 4 letters
Year Columbus returned from his final voyage to the New World, 4 letters
Year Michelangelo's David was completed, 4 letters
Year of Isabella's death, 4 letters
A master's degree in religion, 4 letters